Optimizing periprosthetic fracture management and in-hospital outcome: insights from the PIPPAS multicentric study of 1387 cases in Spain

Background The incidence of all periprosthetic fractures (PPF), which require complex surgical treatment associated with high morbidity and mortality, is predicted to increase. The evolving surgical management has created a knowledge gap regarding its impact on immediate outcomes. This study aimed to describe current management strategies for PPF and their repercussions for in-hospital outcomes as well as to evaluate their implications for the community. Methods PIPPAS (Peri-Implant PeriProsthetic Survival Analysis) was a prospective multicentre observational study of 1387 PPF performed during 2021. Descriptive statistics summarized the epidemiology, fracture characteristics, management, and immediate outcomes. A mixed-effects logistic regression model was employed to evaluate potential predictors of in-hospital mortality, complications, discharge status, and weight-bearing restrictions. Results The study encompassed 32 (2.3%) shoulder, 4 (0.3%) elbow, 751 (54.1%) hip, 590 (42.5%) knee, and 10 (0.7%) ankle PPF. Patients were older (median 84 years, IQR 77–89), frail [median clinical frailty scale (CFS) 5, IQR 3–6], presented at least one comorbidity [median Charlson comorbidity index (CCI) 5, IQR 4–7], were community dwelling (81.8%), and had outdoor ambulation ability (65.6%). Femoral knee PPF were most frequently associated with uncemented femoral components, while femoral hip PPF occurred equally in cemented and uncemented stems. Patients were managed surgically (82%), with co-management (73.9%), through open approaches (85.9%) after almost 4 days (IQR, 51.9–153.6 h), with prosthesis revision performed in 33.8% of femoral hip PPF and 6.5% of femoral knee PPF. For half of the patients, the discharge instructions mandated weight-bearing restrictions. In-hospital mortality rates were 5.2% for all PPF and 6.2% for femoral hip PPF. Frailty, age > 84 years, mild cognitive impairment, CFS > 3, CCI > 3, and non-geriatric involvement were candidate predictors for in-hospital mortality, medical complications, and discharge to a nursing care facility. Management involving revision arthroplasty by experienced surgeons favoured full weight-bearing, while an open surgical approach favoured weight-bearing restrictions. Conclusions Current arthroplasty fixation check and revision rates deviate from established guidelines, yet full weight-bearing is favoured. A surgical delay of over 100 h and a lack of geriatric co-management were related to in-hospital mortality and medical complications. This study recommends judicious hypoaggressive approaches. Addressing complications and individualizing the surgical strategy can lead to enhanced functional outcomes, alleviating the economic and social burdens upon hospital discharge. Level of Evidence Level IV case series. Trial registration: registered at ClinicalTrials.gov (NCT04663893), protocol ID: PI 20-2041. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1186/s10195-024-00746-6.


Introduction
Surgical treatment of periprosthetic fractures (PPF) presents challenges due to factors such as the prosthesis, bone defects, remodelling, and osteoporosis, which may hinder reduction and fixation [1][2][3].Operative strategies aim to maintain joint/prosthesis functionality and typically involve either revising the joint with a new prosthesis or utilizing specifically adapted fixation devices [4].When treating PPF, an assessment of the stability of the prosthesis is recommended; if it is loose, revision should be considered [5].For a well-fixed prosthesis, fixation is preferred.However, an ongoing debate persists regarding whether to revise a loose prosthesis or retain it and fix the fracture, especially in very frail patients [2,[6][7][8][9].Surgical technique and perioperative care significatively impact mortality and outcomes in PPF cases [1,10].Most of the studies available on this topic are retrospective, based on small single-hospital cohorts, cover extended time periods, and primarily focus on femoral PPF [1,11], with limited data available on other locations.
Published studies encompass a wide range of surgical options for treating these fractures, which have evolved substantially in recent years.Retrospective research with outdated data may lack relevance and pertinence.Systematic reviews and meta-analysis highlight the need for prospective research, including registries and trials evaluating the outcomes of these divergent treatment strategies [7,8,10,11].Consequently, determining the optimal management approach, especially for frail patients, is often challenging.Tools for decision-making are essential to mitigate clinical complications, enhance functional outcomes, preserve quality of life, and reduce mortality.The PIPPAS Study Group Journal of Orthopaedics and Traumatology (2024) 25:13 PPF constitute a highly heterogeneous group of relatively rare fractures, making it difficult to report outcomes and study enough patients to draw robust conclusions.The PIPPAS study (Peri-Implant PeriProsthetic Survival Analysis) sought to prospectively enrol a substantial number of patients with PPF and peri-implant fractures (PIF) over a specified timeframe in Spain.The primary objective of this study was to provide insights into current trends in the management strategies for shoulder, elbow, hip, knee, or ankle PPF.Additionally, it aimed to investigate their impact on complications and mortality in the acute setting and their immediate consequences for the community.Furthermore, the study described the epidemiology, incidence, and characteristics of PPF in the Spanish population.This contemporary information on PPF management and its influence on immediate outcomes will be invaluable for addressing factors related to poorer outcomes.

Material and methods
The PIPPAS study was a collaborative multicentre prospective observational case series study that evaluated PPF and PIF in 59 hospitals, covering 37.5% of the Spanish population (17,779,904 individuals).PPF management was the standard of care for each participating site.Patients were recruited consecutively from January 1 to December 31, 2021.Eligible patients were ≥ 18 years old and admitted with a shoulder, elbow, hip, knee, or ankle PPF.Patients with pathologic or intraoperative fractures, failed fixation without a new fracture line, or pregnancy were excluded.All patients or their relatives provided consent for their inclusion.PPF were defined as fractures occurring in a bone sustaining one component of a joint replacement.PPF were classified using the Unified Classification System (UCS) [12].For their analysis, type D PPF were allocated to the arthroplasty group (i.e.shoulder or elbow, hip or knee, knee or ankle) that most conditioned surgical management.
The study aimed to provide valuable information about current trends in management strategies for PPF and PIF, their influence on complications and mortality in the acute setting, and their immediate impact on the community.The study also aimed to describe the epidemiology, incidence, and PPF characteristics in the Spanish population.
We enrolled 1387 patients.We collected information on patient demographics, baseline status, treatment, and hospital care based on the variables proposed in the Fragility Fracture Network (FFN) Minimum Common Dataset for hip fracture registries, which were adapted to the specific nature of PPF (Additional file 1 in Appendix S1).
The incidence of PPF was obtained from the mean annual number of elective joint replacements performed during 2019 and 2021 by all participating hospitals.Signs of X-ray loosening or a painful prosthesis prior to the PPF helped with the differentiation of B1 from B2 fractures if no intraoperative stability tests were done.Candidate predictors of in-hospital mortality, in-hospital medical complications (present or absent), weight-bearing restrictions (allowed or forbidden; only for lower limb PPF, LLPPF), and destination at hospital discharge (own home or nursing care facility) were analysed.Candidate predictors were selected according to clinical relevance.Quantitative variables were categorized based on their median values, except for the Charlson comorbidity index (CCI), clinical frailty scale (CFS), and Pfeiffer, where a significant cut-off value was used (p < 0.05).
The manuscript was adapted to the STROBE statement.The study coordination centre and each participating hospital obtained institutional review board approval.This study was performed following the ethical standards Pfeiffer's SPMSQ-no.Descriptive statistics summarized the epidemiologic data, fracture characteristics, management aspects, and in-hospital outcomes.Continuous variables were summarized as the mean and standard deviation (SD) or the median and interquartile range (IQR) as appropriate (p < 0.05, Shapiro-Wilk test).Categorical variables were summarized as the absolute frequencies and percentages.Relative risk was calculated with the chi-square test.Candidate predictors were analysed using a mixed-effects logistic regression model, and the results were shown as forest plots.Statistical analysis was conducted using RStudio (v.4.1.0;R Foundation for Statistical Computing, Vienna, Austria).Data were collated centrally using the REDCap data entry system (Vanderbilt University, USA) housed on secure servers at the Instituto de Estudio de Ciencias de la Salud de Castilla y León, Spain.
Most patients were managed surgically (82%) under spinal anaesthesia (69%) after almost 4 days of surgical delay (92.5 IQR, 51.9-153.6 h) and through an open approach (85.9%).Femoral knee PPF were the most likely to be treated operatively (90.8%), and pelvic hip PPF were the most likely to be non-operatively managed (45.2%).The stability of prosthetic fixation was not checked in 44.1% of the patients: two-thirds of the femoral hip PPF and less than half of the femoral knee PPF cases.Prosthetic revision was performed in 33.3% of patients with femoral hip PPF, while 93.5% of femoral knee PPF received fixation.Among multiple fixation techniques, the most frequently used was a single plate (56.1%).Patients with lower limb PPF (LLPPF) managed only with fixation had a higher relative risk of being managed with restricted weight-bearing than those having their prosthesis revised (p < 0.01).Table 3 describes the management and surgical techniques for all PPF.
Humeral elbow and patellar PPF are not detailed (n = 4 and n = 5) IQR interquartile range, N/A not available, Pfeiffer′s SPMSQ Pfeiffer′s Short Portable Mental Status Questionnaire, CFS clinical frailty scale, ASA American Society of Anesthesiologists (ASA) physical status classification system, NOAC new oral anti-coagulant, PAA platelet anti-aggregant, Hb haemoglobin * Pre-fracture mobility scale: 1, completely independent gait; 2, independent gait outdoors with one technical aid; 3, independent gait outdoors with two technical aids; 4, independent gait indoors only, with or without aids; 5, no mobility at all or only with the help of two other people ^ Osteoprotective treatment: the percentage for each individual treatment was calculated with respect to the total number of patients receiving osteoprotective treatment The overall in-hospital mortality was 5.1%.At least one medical complication appeared in 42% of the patients: the most common complications were delirium and renal and pulmonary complications.Clinical co-management with geriatricians, internal medicine, or specialties other than anaesthesia was available for 73.9% of patients, and 78.9% required transfusion of at least one unit of packed red blood cells (cut-off level for transfusion: 7.5-8 g/ dL).Regardless of the type of fracture, 77.8% of patients were initially mobilized out of bed within 24-48 h after surgery.Full weight-bearing was allowed for 34.4% of the patients with LLPPF, and 37.2% of patients went to a nursing home after discharge.Table 4 summarizes postoperative care and outcomes until hospital discharge.

Discussion
Despite their low incidence, PPF are severe injuries in older persons [1,6,10,11].Published data are scarce for PPF other than femoral PPF [7,11,13,14].Large sample sizes were necessary to draw conclusions regarding the current management and early outcomes of these patients [15].To our knowledge, this is the largest specific dataset for prospectively collected PPF.The 1-year data collection period (2021) offers an up-to-date view of PPF management.The use of the minimum dataset proposed by the FNN for hip fracture registries makes future comparisons and projections possible.
The incidence and distribution of PPF and differences in sex ratios and age reflect joint replacement indications and life expectancy, which vary among cultures and populations [16].Most series reported a mean age of 64-78 years [2,14,17], which was younger than our population.The femur was the most common location (91%) because THA and TKA are the most implanted joint replacements overall [18,19].
Data related to patients′ pre-fracture health status are usually limited to the ASA scores.Information on CCI, mobility, references to osteoporosis treatment, or place of residence documentation are scarce in previous studies.PIPPAS demonstrated that CFS, CCI, and cognitive impairment were related to poorer immediate outcomes.In frail patients, CFS, CCI, and cognitive status can help complications to be addressed and an adequate surgical strategy to improve functional weight-bearing and to minimize the social burden at hospital discharge to be selected.The percentage of patients with an ASA II score ranges across studies from 24% (in our study) to 54% [11,20], which is probably influenced by differences in age.
The distribution of femoral hip PPF is similar in other published series: around 15% were type A, 70% type B, and 15% type C [2,21].The exception is the Mayo Clinic′s series, where 34.7% of the patients were type A1 [22].In 24 patients, Liu et al. found a higher percentage In-hospital fractures of type C tibia knee PPF than we did: 70.8% vs 39% [14].According to the Mayo Clinic′s series and the review by Carli, postoperative femoral hip PPF were most common with uncemented stems [15,22]; the same is true for hemiarthroplasty [23], which showed different incidences depending on the stem design [22].In our study, as in that of Karam et al., femoral hip PPF occurred equally in cemented and uncemented stems (p = 0.06) [24].We found that femoral knee PPF were more common with uncemented femoral components than with cemented ones (p < 0.01), although Nugent et al. found no difference [25].Detailed analysis of the implant design and fixation method in each joint and type of PPF are needed to clarify their contributions to the PFF risk.
In-hospital mortality for femoral hip PPF ranges from 2.4% to 8% [22,27].This variation may be due to the patients' age and comorbidities, as age and frailty variables favoured in-hospital mortality in our study.Patients managed by a geriatrician had a lower risk of medical complications and in-hospital mortality and a greater chance of returning to the community at hospital discharge (p < 0.05).Therefore, as suggested [1], multidisciplinary co-management starting at diagnosis should be organized to benefit patients with PPF and address potential complications promptly.
A wide range of surgical strategies can be applied to each PPF type, and this range of strategies depends on the PPF type considered [1,2,6,7,9,11,13,14,20]. Surgical management can be grouped into revision arthroplasty or internal fixation.Revision to a long stem is recommended for all type B2 femoral hip PPF, especially transverse patterns [3,28,29].Other series had higher revision rates than seen in the current study: 60.9-86.8%for femoral hip PPF and 19.3% for femoral knee PPF [1,11,14].Recent publications show a trend towards considering internal fixation in Vancouver B2 and B3 fractures [1,2,6,7,9,13,20].PIPPAS showed that revision arthroplasty favoured full weight-bearing and hospital discharge to the patient's own home (p < 0.05), but revision hip arthroplasty for PPF is associated with a high  risk of mortality (p < 0.05) [13], as revealed in this study.We found that the recommendation for routine intraoperative stem stability tests before fixation was not followed, as the stability of one-third of femoral stems was not checked.However, not checking the stability of the prosthesis favoured weight-bearing restrictions (p < 0.05).The reason for this might be that when the stability is checked, the most common surgical strategy is prosthesis revision, which favours full weight-bearing.When the surgical strategy is fixation, usually with plates, surgeons might not feel confident with full weight-bearing.Compared to revision of the prosthesis, patients managed only with fixation showed a higher relative risk of restricted weight-bearing (p < 0.01).There is a tendency to use double plating techniques to increase stability to allow full weight-bearing, although they are not widely used.Anatomical polyaxial locking plates allow less invasive surgical approaches and the placement of locking screws around the stem, thus providing a certain degree of stability to a loose prosthesis [4].Further analysis of the influence of full weight-bearing on failure of fixation rates in LLPPF managed only with fixation should follow.
Therefore, our suggestion is to individualize every case, taking into consideration how frail the patient is and the surgical strategy options that could be used to achieve the best functional outcome in each scenario.Open approaches were related to restricted weightbearing for at least 30 days postoperatively (p < 0.05), but many authors mainly used open approaches for fixation [3,6,7,13,17], even though hypoaggressive approaches are recommended for PPF fixation [4,26].Surgeon experience favoured full weight-bearing (p < 0.05).Competency in the management of PPF could help improve in-hospital outcomes.
The operative delay varies from 6.06 to 4.07 days in published series [6,11,21,31,32].Johnson-Lynn found no association between surgical delay and inpatient mortality [5], but we observed that surgery within the first 100 h (4.17 days) favoured survival and reduced the risk of medical complications (p < 0.05).Patients who are fit for surgery may benefit from prompt surgical management, and co-management may improve their medical condition, limiting the influence of comorbidities on survival and complications.There is limited information regarding the type of anaesthesia in the management of PPF.Haughom et al. reported that 83.4% of patients with femoral hip PPF underwent surgery under general anaesthesia [32], in contrast to 13.8% and 25% of patients with femoral knee and femoral hip PPF in the PIPPAS study.However, the type of anaesthesia did not influence in-hospital outcomes in PPF.
Strut grafts have been widely used in the management of PPF [22], although there is a trend towards limiting their use: 1.4% in COMPOSE [11] and 2.2% in PIPPAS.This may be attributed to the increased use of hypoaggressive approaches and double-plate fixation when additional stability is required.
Non-operative management for femoral PPF is limited to selected cases, with reported rates ranging from 0 to 33% [11,30].Non-operative treatment was a candidate predictor of in-hospital mortality and worse outcomes (p < 0.05).It remains unclear whether the indication for non-surgical treatment was driven by the patient′s comorbidities or the fracture pattern.Nevertheless, it is generally accepted that patients with femoral fractures benefit from surgery [4,33].
Early weight-bearing is a crucial factor in limiting the impact of LLPPF on functional outcomes and the return to the community [34,35].Restricted weight-bearing is associated with limited possibility of returning to the community, resulting in economic and social burdens [34,35].Frailty variables correlated with weight-bearing restrictions and cannot be modified.However, the operative technique can be improved to allow unrestricted weight-bearing, facilitating early functional recovery and social independence [3].
This study has several limitations, including the following.(1) The heterogeneity of PPF-although multiple surgical strategies were employed, the population, management, and outcomes were quite similar.(2) Specific details of and differences between fracture types and their surgical treatments were not explored, so further analysis should follow.A comprehensive understanding of these fractures can assist readers in organizing their resources.(3) Participating sites were responsible for data accuracy.(4) The stability of prosthesis fixation was always determined by the treating site.(5) Candidate predictors provide useful information about the potential correlation between two variables, but they cannot be used to determine casuality.

Fig. 1
Fig. 1 Distribution and types of PPF.The number and percentage (with respect to the total number of PPF) of fractures of each type according to the Unified Classification System (UCS) are shown.The size of each circle is proportional to the number of fractures

Fig. 2
Fig.2Incidence rates of shoulder PPF, elbow PPF, hip PPF, knee PPF, and ankle PPF in the Spanish population.HSA hemishoulderarthroplasty, TSA total shoulder arthroplasty, RSA reverse shoulder arthroplasty, THA total hip arthroplasty, PHA partial hip arthroplasty, TKA total knee arthroplasty, TAA total ankle arthroplasty.

Fig. 3 Fig. 4
Fig. 3 Candidate predictors of in-hospital mortality in patients with a periprosthetic fracture (PPF): alive at hospital discharge vs dies in hospital before hospital discharge.The reference category for each variable is the first value.The size of the box is proportional to the number of patients in the category.CI confidence interval, OR odds ratio, CFS clinical frailty scale, CCI Charlson comorbidity index, MIS minimally invasive surgery, PC percutaneous, MIPO minimally invasive plating osteosynthesis

Fig. 5
Fig. 5 Candidate predictors of destination at hospital discharge in patients with a periprosthetic fracture (PPF): own home vs nursing care.The reference category for each variable is the first value.The size of the box is proportional to the number of patients in the category.CI confidence interval, OR odds ratio, CFS clinical frailty scale, CCI Charlson comorbidity index, MIS minimally invasive surgery, PC percutaneous, MIPO minimally invasive plating osteosynthesis

Fig. 6
Fig. 6 Candidate predictors of weight-bearing restrictions in patients with a lower limb [i.e.hip (pelvis and femur), knee (femur and tibia), and ankle (tibia)] periprosthetic fracture (PPF): full weight-bearing vs restrictions.The reference category for each variable is the first value.The size of the box is proportional to the number of patients in the category.CI confidence interval, OR odds ratio, CFS clinical frailty scale, CCI Charlson comorbidity index, MIS minimally invasive surgery, PC percutaneous, MIPO minimally invasive plating osteosynthesis

Table 1
Demographic and baseline data for patients presenting any periprosthetic fracture (PPF), humeral shoulder PPF, pelvic hip PPF, femoral hip PPF, femoral knee PPF, tibial knee PPF, and tibial ankle PPF

Table 3 (continued) PPF Humeral shoulder PPF Pelvic hip PPF Femoral hip PPF Femoral knee PPF Tibial knee PPF Tibial ankle PPF
Except for "treatment", categorical variables are summarized as the absolute frequency and percentage with respect to the number of patients surgically managed in each group.
IQR interquartile range, MIS minimally invasive surgery, PC percutaneous, ex fix external fixator, mm millimeters, MIPO minimally invasive plating ostheosynthesis, N/A not available

Table 4
(continued)Difference between haemoglobin level at admission and haemoglobin level after surgical treatment or before hospital discharge if patient was managed nonsurgically.+ The percentages for the different osteoprotective treatments at discharge were calculated with respect to the total number of patients who were receiving osteoprotective treatment *